The CNP Micronutrients and Mental Health Research Category consolidates research exploring the interdependent relationship between dietary intake and micronutrients. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Bakian et al. (2020) examined the association between dietary creatine and depression in U.S. adults, using the data on dietary creatine intakes and patient health questionnaires obtained by the 2005 to 2012 National Health and Nutrition Examination Survey (NHANES) on its 22,692 participants (aged ≥20 years). This study compared the depression prevalence in the subjects in the lowest quartile of dietary creatine intake (rate of 10.23/100) to the occurrence in those in the highest quartile of creatine consumption (5.98/100 persons). While an inverse association was confirmed between dietary creatine and depression [adjusted odds ratio (AOR) = 0.68], the strongest correlations were seen in females (AOR = 0.62) and participants not taking antidepressant/anxiolytic medication (AOR = 0.58). These results highlighted a significant negative relationship between creatine intake and depression in a nationally representative cohort. This leaves the role that creatine plays in depression among women and across the lifespan to be investigated in the future.
CNP Research Summary can be found in the CNP Library Membership
Vitamin B12 supplementation: Preventing onset and improving prognosis of depression
Zinc supplementation combined with antidepressant drugs for treatment of patients with depression: A systematic review and meta-analysis
CNP Research Summary can be found in the CNP Library Membership
Vitamin C supplementation promotes mental vitality in healthy young adults: Results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial
Effect of vitamin D supplementation on outcomes in people with early psychosis: The DFEND randomized clinical trial
CNP Research Summary can be found in the CNP Library Membership
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial
Role of magnesium supplementation in the treatment of depression: A randomized clinical trial
CNP Research Summary can be found in the CNP Library Membership
Risk factors for depression. New evidence on selenium deficiency and depressive
An observational preliminary study on the safety of long-term consumption of micronutrients for the treatment of psychiatric symptoms
CNP Research Summary can be found in the CNP Library Membership
A randomised trial of nutrient supplements to minimise psychological stress after a natural disaster
Assessment of dietary adequacy for important brain micronutrients in patients presenting to a traumatic brain injury clinic for evaluation
CNP Research Summary can be found in the CNP Library Membership
Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode
Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial
CNP Research Summary can be found in the CNP Library Membership
The effects of four-week multivitamin supplementation on mood in healthy older women: A randomized controlled trial
The effects of multivitamin supplementation on mood and general well-being in healthy young adults. A laboratory and at-home mobile phone assessment
CNP Research Summary can be found in the CNP Library Membership
Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: A meta-analysis
The effect of multivitamin supplementation on mood and stress in healthy older men
CNP Research Summary can be found in the CNP Library Membership
Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males
CNP Research Summary can be found in the CNP Library Membership
Higher vitamin B 6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study
Multinutrients for the treatment of psychiatric symptoms in clinical samples: A systematic review and meta-analysis of randomized controlled trials
CNP Research Summary can be found in the CNP Library Membership
Serum vitamin D concentrations are associated with depressive symptoms in men: The sixth Korea national health and nutrition examination survey 2014
CNP Research Summary can be found in the CNP Library Membership
Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: A case-control study
Evaluation of some trace elements and vitamins in Major Depressive Disorder patients: A case-control study
CNP Research Summary can be found in the CNP Library Membership
The role and the effect of magnesium in mental disorders: A systematic review
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder
CNP Research Summary can be found in the CNP Library Membership
Vitamin B-6 and depressive symptomatology, over time, in older Latino adults
Greater circulating copper concentrations and copper/zinc ratios are associated with lower psychological distress, but not cognitive performance, in a sample of Australian older adults
CNP Research Summary can be found in the CNP Library Membership
Palmitoylethanolamide counteracts brain fog improving depressive-like behaviour in obese mice: Possible role of synaptic plasticity and neurogenesis
Is there a relationship between chocolate consumption and symptoms of depression? A cross-sectional survey of 13,626 US adults.
CNP Research Summary can be found in the CNP Library Membership
Association between tea consumption and depressive symptom among Chinese older adults
Association of dietary phytochemical index and mental health in women: A cross-sectional study
CNP Research Summary can be found in the CNP Library Membership
Effect of green tea phytochemicals on mood and cognition
The relationship between dietary vitamin K and depressive symptoms in late adulthood: A cross-sectional analysis from a large cohort study
CNP Research Summary can be found in the CNP Library Membership
Nutritional interventions in clinical depression
CNP Research Summary can be found in the CNP Library Membership
The role of elements in anxiety
Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols
CNP Research Summary can be found in the CNP Library Membership
Dietary total antioxidant capacity as a preventive factor against depression in climacteric women
The efficacy and safety of nutrient supplements in the treatment of mental disorders: A meta-review of meta-analyses of randomized controlled trials
CNP Research Summary can be found in the CNP Library Membership
Zinc, magnesium, selenium and depression: A review of the evidence, potential mechanisms and implications
Higher vitamin B6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study
CNP Research Summary can be found in the CNP Library Membership
Association between lower intake of minerals and depressive symptoms among elderly Japanese women but not men: Findings from Shika study
CNP Research Summary can be found in the CNP Library Membership
A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: effects on healthy and 'at-risk' individuals
The association between dietary intake of magnesium and psychiatric disorders among Iranian adults: A cross-sectional study
CNP Research Summary can be found in the CNP Library Membership
Nutrient and genetic biomarkers of nutraceutical treatment response in mood and psychotic disorders: A systematic review
The association between dietary intake of magnesium and psychiatric disorders among Iranian adults: A cross-sectional study
CNP Research Summary can be found in the CNP Library Membership
The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: A systematic review
Low zinc, copper, and manganese intake is associated with depression and anxiety symptoms in the Japanese working population: Findings from the eating habit and well-being study
CNP Research Summary can be found in the CNP Library Membership
Database analysis of depression and anxiety in a community sample—response to a micronutrient intervention
Association of total zinc, iron, copper and selenium intakes with depression in the US adults