Leptin

Leptin, also known as the “satiety hormone”, ” is a circulating hormone secreted primarily by adipocytes (i.e., fat cells) to signal nutritional status in direct proportion to fat stores; as fat stores deplete, leptin levels fall, resulting in increased appetite and decreased energy expenditure to replenish fat stores (Pan & Myers, 2018). Leptin regulates energy homeostasis, neuroendocrine function, and metabolism (Münzberg & Morrison, 2015).