Herbs and Mental Health

The CNP Herbs and Mental Health Research Category consolidates research exploring the application of herbs in psychological and psychiatric health. Jill Troderman is CNP’s Herbs and Mental Health contributor and is the lead developer of this research category. To view each original study on the open internet, click “Original.” To view the CNP summary of the study, click “CNP Summary.” While a small portion of the studies in this research category is available below for free, the full set of studies (and their summaries) are available to CNP members through the CNP Library Membership (launching January 15, 2021).

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CNP Research Summary can be found in the CNP Library Membership

2019

Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study

Original

2019

An investigation into the stress-relieving and pharmacological actions of an Ashwagandha (Withania Somnifera) extract: A randomized, double-blind, placebo-controlled study

Original

2018

Adjunctive use of a standardized extract of Withania somnifera (Ashwagandha) to treat symptom exacerbation in Schizophrenia: A randomized, double-blind, placebo-controlled study

Original

2014

An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb Ashwagandha (Withania somnifera)

Original
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CNP Research Summary can be found in the CNP Library Membership

2019

Efficacy and safety of Ashwagandha (Withania somnifera) root extract in Insomnia and anxiety: A double-blind, randomized, placebo-controlled study

Original

2019

Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment

Original
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CNP Research Summary can be found in the CNP Library Membership

2014

Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study

Original

2015

Curcumin boosts DHA in the brain: implications for the prevention of anxiety disorders

Original
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CNP Research Summary can be found in the CNP Library Membership

2017

Clinical use of Curcumin in depression: A meta-analysis

Original

2013

Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials

Original
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CNP Research Summary can be found in the CNP Library Membership

2016

Effect of lavender scent inhalation on prevention of stress, anxiety and depression in the postpartum period

Original

2009

A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder

Original

2014

Relevance of the anti-inflammatory properties of Curcumin in neurodegenerative diseases and depression

Original

2020

Obstacles against the marketing of Curcumin as a drug

Original
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CNP Research Summary can be found in the CNP Library Membership

2020

Interaction between Gut Microbiota and Curcumin: A new key of understanding for the health effects of Curcumin

Original

2018

Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus

Original
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CNP Research Summary can be found in the CNP Library Membership

2019

A diet enriched with curcumin promotes resilience to chronic social defeat stress

Original

2015

An investigation of the effects of curcumin on anxiety and depression in obese individuals: a randomized controlled trial

Original
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CNP Research Summary can be found in the CNP Library Membership

2016

Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial

Original

2014

An open-label study to elucidate the effects of standardized Bacopa Monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children

Original
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CNP Research Summary can be found in the CNP Library Membership

2019

Neurotransmitter, antioxidant and anti-neuroinflammatory mechanistic potentials of herbal medicines in ameliorating Autism Spectrum Disorder

Original

2017

Phytochemicals in the treatment of Alzheimer's Disease: A systematic review

Original
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CNP Research Summary can be found in the CNP Library Membership

2019

Neuroprotective efficacy of thymoquinone against amyloid beta-induced neurotoxicity in human induced pluripotent stem cell-derived cholinergic neurons

Original

2014

Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress

Original
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CNP Research Summary can be found in the CNP Library Membership

2017

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study

Original

2018

Honokiol exerts antidepressant effects in rats exposed to chronic unpredictable mild stress by regulating brain derived neurotrophic factor level and hypothalamus-pituitary-adrenal axis activity (animal)

Original
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CNP Research Summary can be found in the CNP Library Membership

2021

Effects of Saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: A randomized, double-blind, parallel group, clinical trial

Original

2020

Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis (animal)

Original
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CNP Research Summary can be found in the CNP Library Membership

2020

Valerian root in treating sleep problems and associated disorders-a systematic review and meta-analysis

Original

2016

Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder

Original
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CNP Research Summary can be found in the CNP Library Membership

2018

Acute ingestion of rosemary water: Evidence of cognitive and cerebrovascular effects in healthy adults

Original

2018

Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: From bench research to confirmation in human trials

Original
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CNP Research Summary can be found in the CNP Library Membership

2021

Use of complementary alternative medicine and the associated factors among patients with depression

Original

2020

Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial

Original

2020

Role of 5-HT1A receptor in the anxiolytic-relaxant effects of bergamot essential oil in rodent (animal)

Original

2020

Cannabidiol: A potential new alternative for the treatment of anxiety, depression, and psychotic disorders

Original
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CNP Research Summary can be found in the CNP Library Membership

2017

Effects of Gladiolus dalenii on the stress-induced behavioral, neurochemical, and reproductive changes in rats (animal)

Original

2020

A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression

Original

2019

Dietary intake of the citrus flavonoid hesperidin affects stress-resilience and brain kynurenine levels in a subchronic and mild social defeat stress model in mice (animal)

Original
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CNP Research Summary can be found in the CNP Library Membership

2017

Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis

Original

2018

A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression

Original

2020

Attenuation of anxiety-like behavior by Helichrysum stoechas (L.) Moench methanolic extract through up-regulation of ERK signaling pathways in noradrenergic neurons

Original
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CNP Research Summary can be found in the CNP Library Membership

2021

Putative antidepressant effect of chamomile (Matricaria chamomilla L.) oral extract in subjects with comorbid generalized anxiety disorder and depression

Original

2017

Effects of saffron aqueous extract and its main constituent, crocin, on health-related quality of life, depression, and sexual desire in coronary artery disease patients: A double-blind, placebo-controlled, randomized clinical trial

Original

2020

A placebo controlled randomized clinical trial of Crocus sativus L. (saffron) on depression and food craving among overweight women with mild to moderate depression

Original
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CNP Research Summary can be found in the CNP Library Membership

2018

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance

Original
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CNP Research Summary can be found in the CNP Library Membership

2018

Effects of aromatherapy with Rosa damascena on nulliparous women's pain and anxiety of labor during first stage of labor

Original

2021

The effect of ginsenosides on depression in preclinical studies: A systematic review and meta-analysis

Original
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CNP Research Summary can be found in the CNP Library Membership

2019

Ameliorative effects of Radix rehmanniae extract on the anxiety- and depression-like symptoms in ovariectomized mice: A behavioral and molecular study

Original

2019

Anti-depressive effectiveness of baicalin in vitro and in vivo

Original
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CNP Research Summary can be found in the CNP Library Membership

2020

The effects of Lavender and Chamomile essential oil inhalation aromatherapy on depression, anxiety and stress in older community-dwelling people: A randomized controlled trial

Original

2020

Curcumin for depression: a meta-analysis

Original

2020

Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

Original

2019

Baicalin regulates the dopamine system to control the core symptoms of ADHD

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