Neuropods are specialized extensions of certain enteroendocrine cells (EECs) in the gut that form direct synaptic connections with vagal afferent neurons. Unlike traditional hormone-based signaling, neuropods use rapid neurotransmission, primarily via glutamate, to relay nutrient information to the brain within milliseconds. This allows the brain to detect and respond to caloric content in real time, influencing appetite, food preference, and reward-driven eating behavior.
