The gut lumen is the hollow interior space inside the gastrointestinal tract (GIT), starting from the mouth and extending to the anus. It is the region of the GI tract where ingested food and liquids are mixed with digestive secretions and undergo chemical and mechanical digestion. The gut lumen is surrounded by the other parts of the intestinal wall: the mucosa, the submucosa, the muscularis, and the serosa. It is also home to diverse microbial species known as gut microbiota.
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