Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice
The CNP Diet, Depression, and Anxiety Research Category consolidates research exploring the interconnected relationship between dietary intake, depression, and anxiety. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
This 2022 review analyzed a collection of research articles that used dietary interventions as a treatment for depression among adult populations. No funding was provided for this review. Firstly there was a systematic search conducted on several databases to find studies treating adults with depression using either whole food or whole diet interventions. The studies were then assessed for quality using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Seven studies met the eligibility criteria, composed of 49,156 participants in total. All seven of these studies reported improvement of depressive outcomes following dietary intervention. The effect size, which calculates the strength of the relationship between the dietary intervention and depressive outcome, varied from small to very large. The data generated and reviewed was limited by the inconsistency in some of these research papers. Nevertheless, the overall findings indicate that eating fresh produce, wholegrains, low-fat dairy, and foods with lean protein is beneficial in depression. In addition, positive results were observed for reducing the intake of processed and high-fat foods.
Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice
Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats (animal)
CNP Research Summary can be found in the CNP Library Membership
HFD-induced energy states-dependent bidirectional control of anxiety levels in mice (animal)
Saturated fatty acid is a principal cause of anxiety-like behavior in diet-induced obese rats in relation to serum lysophosphatidyl choline level (animal)
CNP Research Summary can be found in the CNP Library Membership
A modified Mediterranean dietary intervention for adults with major depression: Dietary protocol and feasibility data from the SMILES trial
A high polyphenol diet improves psychological well-being: The polyphenol intervention trial (PPhIT)
CNP Research Summary can be found in the CNP Library Membership
Effects of polyphenols in a Mediterranean diet on symptoms of depression: A systematic literature review
Association between depression and fruit and vegetable consumption among adults in South Asia
CNP Research Summary can be found in the CNP Library Membership
Preventing the recurrence of depression with a Mediterranean diet supplemented with extra-virgin olive oil. The PREDI-DEP trial: Study protocol