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Enhancement of memory and emotional functions by long-term ingestion of protease-treated porcine liver extract in mice
Interest in how diet affects brain function has been growing. Previous research demonstrated that consuming protease-treated porcine liver decomposition product (PLDP) can enhance cognitive performance in humans. In the present study by Kurihara et al. (2025), the authors investigated the impact of PLDP on cognitive and emotional behavior in mice. Over a 16-week period, mice were fed a PLDP-supplemented diet and underwent various behavioral tests. Mice that consumed the PLDP diet showed improved long-term memory, as demonstrated by their performance in the Barnes maze. They also displayed fewer anxiety- and depression-like behaviors in assessments such as the open-field test, elevated plus maze, marble-burying test, and forced swim test. Additionally, these mice showed increased levels of physical activity. RNA sequencing of their brain tissue revealed significant alterations in gene expression, particularly in pathways associated with memory formation, learning, and anxiety regulation. These findings suggest that PLDP affects gene expression related to brain function and may contribute to improved cognition and emotional stability. Overall, the study enhances understanding of how nutrition influences brain health and highlights PLDP’s potential as a dietary intervention to support cognitive and psychological well-being. [NPID: Porcine liver, nutrition, memory, anxiety, locomotor activity]
Year: 2025
