Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation
Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation
CNP Research Summary can be found in the CNP Library Membership
Microbiome and cognitive impairment: Can any diets influence learning processes in a positive way?
A psychology of the human brain-gut-microbiome axis
CNP Research Summary can be found in the CNP Library Membership
The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders
Crosstalk between the gut microbiota and the brain: An update on neuroimaging findings
Association of loneliness and wisdom with gut microbial diversity and composition: An exploratory study
CNP Research Summary can be found in the CNP Library Membership
Crosstalk between the microbiota-gut-brain axis and depression
Perturbations in gut microbiota composition in psychiatric disorders: A review and meta-analysis
CNP Research Summary can be found in the CNP Library Membership