Gutted! Unraveling the role of the microbiome in major depressive disorder
CNP Research Summary can be found in the CNP Library Membership
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
Gutted! Unraveling the role of the microbiome in major depressive disorder
CNP Research Summary can be found in the CNP Library Membership
Nutritional modulation of immune and central nervous system homeostasis: the role of diet in development of neuroinflammation and neurological disease
The gut microbiome and mental health: What should we tell our patients?: le microbiote intestinal et la santé mentale : que devrions-nous dire à nos patients?
CNP Research Summary can be found in the CNP Library Membership
From gut dysbiosis to altered brain function and mental illness: Mechanisms and pathways
Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: Opinion papers of the MyNewGut project
Depressed gut? The microbiota-diet-inflammation trialogue in depression
The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments
Harnessing gut microbes for mental health: Getting from here to there
CNP Research Summary can be found in the CNP Library Membership
Seeing the wood for the trees: A new way to view the human intestinal microbiome and its connection with non-communicable disease