The relationships between vitamin K and cognition: A review of current evidence

This 2019 review analysed the evidence of direct correlations between vitamin K intake and cognitive performances, and looked at the involvement of vitamin K antagonists (VKAs) in reduced cognitive performance. In vitro and animal studies have highlighted vitamin K’s involvement in brain cell development and survival, and have alluded to its anti-apoptotic (apoptosis is cell death) and anti-inflammatory effects. Vitamin K is also involved in sphingolipid metabolism, which is a class of lipids that may be related to neuroinflammation and neurodegeneration if expression in its profile changes. Some studies have pointed at vitamin K antagonists possessing negative influence on cognitive domains such as visual memory, verbal fluency, and brain volume. This review examined vitamin k, VKAs, and cognitive function in view of an expected increase in prevalence of Alzheimer’s disease and other forms of dementia.
[NPID: cognition, vitamin K, cognitive performance, anti-inflammatory, lipids, neuroinflammation, neurodegeneration, visual memory, verbal fluency, brain volume, dementia, Alzheimer’s]

Year: 2019

Reference: Alisi, L., Cao, R., De Angelis, C., Cafolla, A., Caramia, F., Cartocci, G., Librando, A., & Fiorelli, M. (2019). The Relationships Between Vitamin K and Cognition: A Review of Current Evidence. Frontiers in neurology, 10, 239. https://doi.org/10.3389/fneur.2019.00239