A short-term, high-caloric diet has prolonged effects on brain insulin action in men

This research article examines the relationship between brain insulin responsiveness and long-term weight gain, as well as unhealthy body fat distribution. The findings indicate that short-term consumption of calorie-dense sweet and fatty foods leads to liver fat accumulation and disrupts brain insulin action, effects that persist beyond the period of dietary excess. The study highlights that the brain’s insulin response can adapt to transient dietary changes before weight gain becomes apparent, potentially contributing to the onset of obesity and related health conditions. [NPID: Brain insulin, short-term consumption, calorie-dense, sweet and fatty, obesity]

Year: 2025

Reference: Kullmann, S., Wagner, L., Hauffe, R., Kühnel, A., Sandforth, L., Veit, R., Dannecker, C., Machann, J., Fritsche, A., Stefan, N., Preissl, H., Kroemer, N. B., Heni, M., Kleinridders, A., & Birkenfeld, A. L. (2025). A short-term, high-caloric diet has prolonged effects on brain insulin action in men. Nature Metabolism, 7(3), 469-477. https://doi.org/10.1038/s42255-025-01226-9