Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder
This retrospective case study by Laurent (2024) evaluates the efficacy of Ketogenic Metabolic Therapy (KMT) in a patient with bipolar disorder who had treatment-resistant depressive symptoms, which were insufficiently controlled by weekly ketamine treatments. The study aims to assess the potential benefits of KMT for improving mood stabilization and overall functioning in this patient. In addition to mood evaluations using the Depression Anxiety Stress Scales (DASS), Generalized Anxiety Disorder-7 (GAD-7), and PTSD Checklist for DSM-5 (PCL-5), the patient’s interventions included tracking biomarkers linked to ketone genesis and macronutrient levels. These tools were used to measure mood stability, anxiety, and depression over time alongside qualitative evaluations of life quality and mental well-being. The results revealed significant mood stabilization, with improvements in functionality and mental well-being. The patient showed notable reductions in anxiety and depression symptoms, as well as enhanced life quality and overall functioning. Both quantitative data from the psychiatric assessment tools and qualitative feedback underscored the positive impact of KMT on the patient’s mental health. This case study contributes to the field of metabolic psychiatry, suggesting that KMT may offer substantial benefits for patients with treatment-resistant bipolar disorder, particularly those with depressive symptoms. The integration of both quantitative psychiatric measures and qualitative insights highlights the potential of KMT in improving mood stabilization and quality of life in such patients. [NPID: Ketogenic diet, bipolar disorder, KMT, ketogenic metabolic therapy, metabolic psychiatry, mood disorders, treatment-refractory depression, clinical psychology]
Year: 2024
