Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract (animal)

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Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet

The purpose of this 2018 study was to determine if a western diet changes brain metabolism, increases blood-brain barrier (BBB) transport and inflammation, and induces cognitive impairment in C57BL/6 (WT) mice and low-density lipoprotein receptor null (LDLr -/-) mice (a model of hyperlipidemia and cognitive decline). Cognitive processes (assessed by Y-maze and radial arm water […]

The impact of saturated fat, added sugar and their combination on human hippocampal integrity and function: A systematic review and meta-analysis

Impact of Western-Style Diet on Hippocampal Function and Brain Health in Humans Similar to findings in animal research, emerging evidence suggests that a Western-style (WS) diet—characterized by high levels of saturated fat and added sugar—negatively affects human hippocampal function. However, the specific conditions under which this impairment occurs remain unclear, and some studies have failed […]