Gut microbiota as a therapeutic target to ameliorate the biochemical, neuroanatomical, and behavioral effects of traumatic brain injuries

While effective traumatic brain injury treatments are currently limited, Rice et al. (2019) believe that gut microbiome manipulation through intake of probiotics may have potential in ameliorating the pathology and symptoms of traumatic brain injury (TBI). The aim of this review was to explore this potential and to describe the role of the gut microbiome in the biochemical, neuroanatomical, and behavioral/cognitive consequences of traumatic brain injury. Firstly, the review explains that the gut microbiome is involved in the alteration of several cellular and molecular processes that are important to the progression of TBI-induced pathologies such as neuroinflammation, immune system response, and intestinal motility and permeability. Gut dysbiosis, which is the disruption of gut microbiota composition, has been found to contribute to TBI-related neuropathology and impaired behavioral outcomes. Other animal model studies have indicated that gut dysbiosis worsens behavioral problems in test subjects with traumatic brain injury and spinal cord injury. Gut dysbiosis has also demonstrated negative effects in murine stroke models. Recent studies involving stroke and spinal cord injury models have showcased the potential of microbiota transplants and probiotics in mitigating neuroanatomical damage and functional impairments. Probiotics have been shown to reduce infection rate in hospitalized patients with brain trauma, and to reduce time spent in intensive care. Perturbed gut microbiota composition and its metabolite profile have been suggested as markers for injury severity and progression. [NPID: trauma, brain injury, brain trauma, gut microbiome, gut-brain axis, gut microbiota, neuroinflammation, immunity, immune system, immune system response, intestinal motility, intestinal permeability, digestion, gut dysbiosis, spinal cord injury, the spine, probiotics, infection]

Year: 2019

Reference: Rice, M. W., Pandya, J. D., & Shear, D. A. (2019). Gut Microbiota as a Therapeutic Target to Ameliorate the Biochemical, Neuroanatomical, and Behavioral Effects of Traumatic Brain Injuries. Frontiers in neurology, 10, 875. https://doi.org/10.3389/fneur.2019.00875

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