Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay

While a series of long-lasting neuropathological molecular and biochemical secondary injuries follow primary traumatic brain injury, which may lead to neuronal damage and death, this 2020 review states that lifestyle factors such as diet may contribute to the development of worse outcomes following brain injury. In fact, poor dietary consumption is expected to exacerbate the secondary damage caused by traumatic brain injury. The aim of this review was to discuss the pathophysiological consequences of eating a Western diet that can lead to the exacerbation of traumatic brain injury (TBI) outcomes. Shaito et al. describe the role of mitochondrial dysfunction, oxidative stress, neuroinflammation, and neuronal injury in TBI circumstances. Following analysis of the currently available data, the conclusion was drawn that the intake of a diet saturated in fats (before or after TBI) aggravates traumatic brain injury, reduces response to treatment, and prevents recovery from brain trauma. [NPID: trauma, traumatic brain injury, mitochondrial dysfunction, oxidative stress, neuroinflammation, neuronal injury, saturated fat, recovery]

Year: 2020

Reference: Shaito, A., Hasan, H., Habashy, K. J., Fakih, W., Abdelhady, S., Ahmad, F., Zibara, K., Eid, A. H., El-Yazbi, A. F., & Kobeissy, F. H. (2020). Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay. EBioMedicine, 57, 102829. https://doi.org/10.1016/j.ebiom.2020.102829