Ghrelin and orexin interact to increase meal size through a descending hippocampus to hindbrain signaling pathway

This research article examines the relationship between brain insulin responsiveness and long-term weight gain, as well as unhealthy body fat distribution. The findings indicate that short-term consumption of calorie-dense sweet and fatty foods leads to liver fat accumulation and disrupts brain insulin action, effects that persist beyond the period of dietary excess. The study highlights […]

In addition to stimulating feeding, hunger is an internal state that serves as a contextual cue for higher-order regulation of anticipatory food-related behavior. The ability of the ventral hippocampus to distinguish between optimum behavior in diverse settings is essential, but it is unclear how internal factors, like hunger, affect the structure of the hippocampus. In […]