Fish consumption, cognitive impairment and dementia: An updated dose-response meta-analysis of observational studies

Cognitive impairment is expected to impact a significant portion of the aging population, and lifelong dietary habits are thought to play a role in preventing cognitive decline. Eating fish has been well-researched for its possible advantages for brain health, among other dietary considerations. This study by Godos et al. (2024) aims to conduct a meta-analysis of observational research examining the relationship between fish consumption and cognitive decline and different forms of dementia. A systematic search of electronic databases identified observational studies that provided quantitative data on fish intake and relevant outcomes (n = 35 publications). Dementia, Alzheimer’s disease, and cognitive impairment/decline were less common in those who ate the most fish. The dose-response analysis showed a significant reduction in the risk of cognitive decline and other cognitive outcomes with higher fish intake, with a 30% lower risk at 150g/day. The outcomes differed according to whether the APOE ε4 allele was present. In conclusion, the results imply that eating fish is dose-dependently linked to a lower risk of cognitive deterioration. To support the evidence of its effects on dementia and Alzheimer’s disease, more study is necessary. [NPID: Fish, Dementia, cognitive status, Alzheimer’s disease, meta-analysis]

Year: 2024

Reference: Godos, J., Micek, A., Currenti, W., Franchi, C., Poli, A., Battino, M., Dolci, A., Ricci, C., Ungvari, Z., & Grosso, G. (2024). Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies. Aging Clinical and Experimental Research, 36(1), 171. https://doi.org/10.1007/s40520-024-02823-6

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