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Effects of fish oil supplementation on bone turnover markers in depression: A pilot study
The use of antidepressants, depression, and bone loss are all known to be related. N-3 PUFA supplementation has been suggested as an effective adjunct treatment for both bone loss and depression. It is yet unknown, nevertheless, how n-3 PUFA affects bone metabolism in depressed people. This pilot study by Wang F. et al. (2024) aimed to explore changes in bone metabolism in depression and assess the effectiveness of fish oil supplementation on bone loss in depressed individuals. The study concentrated on how n-3 PUFA supplementation affected bone turnover indicators in depression, how these changes were related to clinical features, and how these changes affected the markers. It was a secondary analysis and a case-control study of a previously published randomized clinical trial (NCT03295708) that assessed the impact of n-3 PUFA supplementation in depressed patients receiving venlafaxine. The findings demonstrated that at baseline, depressed individuals’ N-terminal propeptides of type I collagen (PINP) levels were considerably greater than those of healthy controls. The secondary analysis revealed significant differences in type I collagen (CTX) and osteocalcin (OSTEOC) between the n-3 PUFA and placebo groups. CTX and OSTEOC levels dropped in the placebo group, suggesting that venlafaxine medication lowers indicators for both bone growth and resorption. In contrast, the n-3 PUFA group showed increased levels of OSTEOC and PINP. Furthermore, the changes in bone turnover markers were consistent with improvements in clinical symptoms. In conclusion, those with drug-naïve depression who receive their first diagnosis exhibit active bone growth. Potential methods for preventing and treating bone loss in depression are suggested by the fact that n-3 PUFA supplementation increases bone formation while venlafaxine appears to decrease bone remodeling. [NPID: major depressive disorder, n-3 PUFA, bone formation, bone resorption, bone loss]
Year: 2024
