Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Shafiee et al. (2018) conducted a large population-based, cross-sectional study examining the association between depression/anxiety symptoms with serum pro-oxidant-antioxidant balance (PAB) in 7,516 adults (62% female; 38% male; age 35-65). It was driven by the fact that depression and anxiety are significantly associated with inflammation, while inflammatory-related conditions are related to oxidative stress resulting from a disturbance in PAB. Serum PAB values increased incrementally across the four groups (none or minimal, mild, moderate, and severe depression) in both men and women (Ptrend < 0.001 among men and Ptrend = 0.005 among women). Analysing the data on anxiety, serum PAB values increased significantly across the four groups in men (Ptrend = 0.02) but not in women (Ptrend = 0.2). The adjusted odds ratios for serum PAB values among men with severe depression and anxiety symptoms were 1.75 and 1.27, respectively, while those among women were 1.40 and 1.17, respectively. It appears that depression and anxiety symptoms are associated with higher degrees of oxidative stress, expressed by greater serum PAB values. [NPID: depression, anxiety, antioxidants, inflammation, oxidative stress, PAB]

Year: 2018

Reference: Shafiee, M., Ahmadnezhad, M., Tayefi, M., Arekhi, S., Vatanparast, H., Esmaeili, H., Moohebati, M., Ferns, G. A., Mokhber, N., Arefhosseini, S. R., & Ghayour-Mobarhan, M. (2018). Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study. Journal of affective disorders, 238, 491–498. https://doi.org/10.1016/j.jad.2018.05.079