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Breakfast skipping is linked to a higher risk of major depressive disorder and the role of gut microbes: a mendelian randomization study
According to earlier observational studies, missing breakfast and having an unbalanced gut microbiota may raise your chance of developing major depressive disorder (MDD). Nevertheless, it is still unknown if the association between MDD and missing breakfast is influenced by alterations in gut flora. This work by Guo et al. (2024) used genome-wide association studies (GWAS) on gut flora, MDD, and missing breakfast to perform a two-step Mendelian randomization (MR) analysis. The objective was to evaluate the function of gut microorganisms (N = 18,340) and investigate causal relationships between MDD (N = 1,815,091) and missing breakfast (N = 193,860). The study discovered that skipping breakfast was linked to a higher risk of MDD, even though there was no association between the two conditions. The MR analysis revealed little indication of a relationship between the quantity of gut bacteria and skipping breakfast, even after controlling for multiple comparisons. Only the abundance of Class Actinobacteria, out of 21 gut microorganisms with IVs available, was substantially linked to a lower risk of MDD. The study revealed no evidence that gut microbiome richness significantly influences the association between missing breakfast and an increased risk of MDD. To fully elucidate these findings, larger investigations are required. [NPID: Breakfast skipping, microbiome, major depressive disorder, mendelian randomization]
Year: 2024
