A longitudinal study of dietary inflammatory index and quality of life in people with osteoarthritis: data from the Osteoarthritis Initiative database

The Dietary Inflammatory Index (DII) has been linked to quality of life (QoL) in individuals with osteoarthritis (OA), but little research has examined how QoL changes over time in relation to DII. This study by Chen et al. (2025) explores the association between DII and quality of life trajectories and investigates whether physical activity moderates this relationship in individuals with osteoarthritis. Data from the Osteoarthritis Initiative database included baseline measurements and follow-ups over 1, 2, 3, 4, 5, 6, and 8 years, using the 12-item Short-Form Health Outcome Survey (assessing physical and mental health) and sociodemographic factors. Data analysis identified three QoL profiles: low physical-low mental QoL (14.5%), low physical-high mental QoL (27.1%), and high physical-high mental QoL (58.4%). Further analysis revealed that individuals with higher DII scores were more likely to belong to the low physical-low mental and low physical-high mental QoL groups rather than the high physical-high mental group. Moreover, higher physical activity levels mitigated the negative effects of elevated DII on QoL. The findings suggest that a high DII is linked to poorer QoL, but increased physical activity may help counteract these negative effects. [NPID: Osteoarthritis, dietary inflammatory index, quality of life, longitudinal study, structural equation model]

Year: 2025

Reference: Chen, Z., Zhang, H., Jin, J., Su, C., Chen, H., & Li, B. (2025). A longitudinal study of dietary inflammatory index and quality of life in people with osteoarthritis: data from the Osteoarthritis Initiative database. Scientific Reports, 15(1), 6024. https://doi.org/10.1038/s41598-025-86431-y