The microbiome-gut-brain axis regulates social cognition & craving in young binge drinkers
CNP Research Summary can be found in the CNP Library Membership
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
The microbiome-gut-brain axis regulates social cognition & craving in young binge drinkers
CNP Research Summary can be found in the CNP Library Membership
The role of diet in shaping human gut microbiota
Association between depression, anxiety symptoms and gut microbiota in Chinese elderly with functional constipation
CNP Research Summary can be found in the CNP Library Membership
The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets
Guts imbalance imbalances the brain: A review of gut microbiota association with neurological and psychiatric disorders
CNP Research Summary can be found in the CNP Library Membership
The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adults
Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses
CNP Research Summary can be found in the CNP Library Membership
Interplay of metabolome and gut microbiome in individuals with major depressive disorder vs control individuals
Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis