Steroids, stress and the gut microbiome-brain axis
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
Steroids, stress and the gut microbiome-brain axis
Can gut microbes play a role in mental disorders and their treatment?
CNP Research Summary can be found in the CNP Library Membership
Can microbiology affect psychiatry? A link between gut microbiota and psychiatric disorders
CNP Research Summary can be found in the CNP Library Membership
Gut microbiota’s effect on mental health: The gut-brain axis
Mind-altering with the gut: Modulation of the gut-brain axis with probiotics
The gut-brain axis in the neuropsychological disease model of obesity: A classical movie revised by the emerging director “microbiome”
CNP Research Summary can be found in the CNP Library Membership
The importance of diet and gut health to the treatment and prevention of mental disorders
CNP Research Summary can be found in the CNP Library Membership
Anxiety, depression, and the microbiome: A role for gut peptides
Effects of psychological, environmental and physical stressors on the gut microbiota
CNP Research Summary can be found in the CNP Library Membership