Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
The microbiota-gut-brain axis
The impact of gut microbiota disorders on the blood-brain barrier
CNP Research Summary can be found in the CNP Library Membership
Diet and microbiota linked in health and disease
CNP Research Summary can be found in the CNP Library Membership
Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health
CNP Research Summary can be found in the CNP Library Membership
Dietary effects on human gut microbiome diversity
CNP Research Summary can be found in the CNP Library Membership
Gut microbiota composition correlates with diet and health in the elderly
Fermented foods, the gut and mental health: A mechanistic overview with implications for depression and anxiety