Trait energy and fatigue may be connected to gut bacteria among young physically active adults: An exploratory study
CNP Research Summary can be found in the CNP Library Membership
The CNP Microbiota-Gut-Brain Axis (MGBA) & Mental Health Research Category consolidates research exploring the interconnected relationship between dietary intake, the microbiome, and the gut-brain axis in the adult population. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.
Major depressive disorder (MDD), being a complicated condition in nature, affects 280 million individuals globally and is a primary cause of disability. Numerous environmental variables, including medicines, nutrition, and microorganisms, have a role in the pathophysiology of depression disorders. The host immune system, genetics, and epigenetics are some of the contributors to the intricate underlying causes of depression. Alterations to intestinal microbiota and their metabolites affect how people with depressive disorders respond to stress and behave in social situations by influencing immune cell maturation and brain neurogenesis, which is mediated by epigenetic changes. In this study, Nohesara et al. (2023) address the possible contributions of dysregulated gut permeability to the emergence of depressive illnesses through changes in metabolites generated from the gut microbiota that have epigenetic consequences. In addition, the authors discuss how changes in the makeup of the gut microbiota might lead to epigenetic changes that can cause depressive illnesses. Focus is shed on the potential benefits of microbiota-derived metabolites, such as probiotics, butyrate (which acts as an epigenetic modifier), polyphenols, medications (such as antibiotics, antipsychotics, and antidepressants), maternal diet, and fecal microbiota transplantation, in mitigating depressive-like behaviors through altering the epigenetic landscape. Lastly, the authors review the difficulties and potential solutions connected to current treatment techniques for depressive disorders via microbiome-related epigenetic changes.
Trait energy and fatigue may be connected to gut bacteria among young physically active adults: An exploratory study
CNP Research Summary can be found in the CNP Library Membership
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients
CNP Research Summary can be found in the CNP Library Membership
The role of the gut microbiota in the development and progression of major depressive and bipolar disorder
The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?
CNP Research Summary can be found in the CNP Library Membership
Association of the gut microbiota with cognitive function in midlife
Gut microbiota in depression: A focus on ketamine
CNP Research Summary can be found in the CNP Library Membership
The gut microbiome and mental health: Implications for anxiety- and trauma-related disorders
Gut-microbiota-targeted diets modulate human immune status
CNP Research Summary can be found in the CNP Library Membership