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Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases
Misfolded amyloid proteins gradually accumulate in both intracellular and extracellular areas, which is one of the main causes of synaptic damage and impaired neural connectivity in a number of neurodegenerative illnesses. While there are still no effective cures for these illnesses, research efforts are continuous. Over the last few decades, many synthetic chemicals, medications, and small molecules have been tested; nevertheless, only few of them have shown efficacy in preventing amyloid protein aggregation and reduction of neurotoxic consequences. Curcumin (Cur), a naturally occurring polyphenol, has recently been demonstrated potential anti-inflammatory, anti-amyloid, and neuroprotective effects in a number of neurodegenerative illnesses. Cur is being hailed as a potential therapy for age-related brain disorders due to its pleotropic effects on the central nervous system, which include a binding bias to amyloid proteins. In this study by Maiti & Dunbar (2018), the authors highlight the use of Cur’s molecular targeting to treat several animal models of neurodegenerative disorders by rescuing neuronal damage, lowering amyloid load, and regaining normal cognitive and sensory motor skills. In particular, Cur may be used as a possible therapy for prion disorders, Alzheimer’s, Parkinson’s, and Huntington’s illnesses. The authors discuss the main drawbacks and restrictions of using Cur to treat various illnesses, as well as workarounds for those drawbacks, in addition to offering detailed advice on the ideal dosage of Cur to treat neurological conditions. [NPID: Neurodegenerative diseases, amyloidosis, curcumin, neuroinflammation, antiamyloid, molecular chaperones, natural polyphenol]
Year: 2018
