The relationship between diet, depression, and Alzheimer’s disease: A narrative review

In this narrative review by Al Shamsi et al. (2024), the authors explore how dietary intake plays a role in the connection between depression and Alzheimer’s disease (AD), as depression and AD were found to co-occur frequently, with depression independently raising the risk of developing AD in the future. Current research findings postulate that diet’s role may influence the risk of both conditions, impacting them both directly and indirectly. Dietary factors impact neurochemical and biological processes that may contribute to the onset and progression of both depression and cognitive decline. While the specific dietary components that provide the most protection against depression and AD remain unclear, current evidence points to the importance of polyphenols, folate, B vitamins, and polyunsaturated fatty acids. Additionally, following dietary patterns like the Mediterranean diet, which incorporates a variety of beneficial foods, is associated with a reduced risk. The study of diet’s role in preventing depression and AD is a relatively new area of research. To better understand the intricate links between diet, depression, and AD, the authors recommend investigating more detailed, long-term datasets and the use of advanced analytical methods. There is an urgent need for further research to develop effective strategies for promoting mental and physical health as people age. [NPID: Diet, depression, Alzheimer’s disease, cognitive decline, polyphenols, folate, B vitamins, polyunsaturated fatty acids, Mediterranean Diet, mental health]

Year: 2024

Reference: Al Shamsi, H. S. S., Rainey‐Smith, S. R., Gardener, S. L., Sohrabi, H. R., Canovas, R., Martins, R. N., & Fernando, W. M. A. D. B. (2024). The relationship between diet, depression, and Alzheimer's disease: A narrative review. Molecular Nutrition & Food Research, 68(13). https://doi.org/10.1002/mnfr.202300419