The impact of chronic intestinal inflammation on brain disorders: The microbiota-gut-brain axis

This 2019 review describes the key cellular signaling pathways underlying chronic intestinal inflammation and the impacts of chronic intestinal inflammation and dysbiosis (disruption of gut microbiota balance) on brain disorders. Serra et al. explain that dysbiosis is closely associated with chronic intestinal inflammation, contributing to the development of chronic intestinal diseases, as well as brain pathologies (neurodegenerative, neurodevelopmental, and psychiatric disorders). Since gut microbiota play a crucial role in the communication that takes place between the gut and the brain, this microbiota-gut-brain axis has been heavily investigated in this field of research. Focusing on the relevant and recent preclinical and clinical studies, this review also presents evidence on the probiotics and prebiotics that hold potential as targets for the microbiota-gut-brain axis and as treatments for these brain disorders. [NPIDs: gastrointestinal disorders, intestinal inflammation, dysbiosis, gut microbiota, brain disorders, chronic intestinal inflammation, neurodegenerative disorders, neurodevelopmental disorders, psychiatric disorders, gut-brain axis]

Year: 2019

Reference: Serra, D., Almeida, L. M., & Dinis, T. (2019). The Impact of Chronic Intestinal Inflammation on Brain Disorders: the Microbiota-Gut-Brain Axis. Molecular neurobiology, 56(10), 6941–6951. https://doi.org/10.1007/s12035-019-1572-8

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