The gut microbiota-immune-brain axis: Therapeutic implications

Role of the Microbiota-Gut-Brain Axis in Human Health

Human health is greatly impacted by the microbiota-gut-brain axis, which affects behavior, brain activity, and gastrointestinal function. A key communication pathway within this axis is the immune system, which connects the gut microbiome to neuroinflammatory processes in both health and disease.

Findings from Recent Review on Gut-Brain-Immune Axis

This review by O’Riordan et al. (2025) explores the ways in which gut microbiota interact with the brain, emphasizing the roles of innate and adaptive immunity, which are frequently disrupted in disorders related to the gut-brain axis. The authors also go into the findings’ wider ramifications and the value of multidisciplinary study in developing this area. A deeper understanding of how microbiota-driven immune regulation functions could lead to innovative precision-based clinical approaches for psychiatric, neurodevelopmental, and neurological disorders. [NPID: microbiome-gut-immune-brain axis, innate immunity, adaptive immunity, gut microbiota]

Year: 2025

Reference: O’Riordan, K. J., Moloney, G. M., Keane, L., Clarke, G., & Cryan, J. F. (2025). The gut microbiota-immune-brain axis: Therapeutic implications. Cell Reports Medicine, 101982. https://doi.org/10.1016/j.xcrm.2025.101982