Navigation
The association between insulin resistance and depressive symptoms – A national representative cross-sectional study
A growing body of research indicates that depression and insulin resistance (IR) are positively correlated. The question of whether there are variations based on sex or body mass index is still up for debate, and very few research have examined specific symptom categories. Therefore, the current study by Rhee et al. (2023) sought to elucidate the impacts of body mass index and sex, as well as to analyze the relationship between IR and categories of depressive symptoms. Four thousand seven individuals, ages 19 to 79, from the National Health and Nutrition Examination Study (South Korea, 2020) made up the study sample. The Patient Health Questionnaire-9 (PHQ-9) and associated variables, as well as information on circulating insulin and glucose levels, were provided by the participants during health interviews and exams. The insulin resistance evaluation utilizing the homeostasis model was used to compute IR. The authors discovered a statistically significant correlation between IR and PHQ-9 total scores. Since the connection was only significant in those who were not obese, only differences related to body mass index were statistically significant. Somatic and cognitive/affective depression symptom categories were linked to IR. Similar findings were obtained using sensitivity analysis. The authors conclude that, in non-obese people, IR was positively correlated with cognitive/affective and somatic depression symptoms. [NPID: Body mass index, depression, insulin resistance, negative binomial distribution]
Year: 2023
