Role of 5-HT1A receptor in the anxiolytic-relaxant effects of bergamot essential oil in rodent (animal)

This 2020 article is centered on the essential oils extracted from the fresh fruit of Citrus bergamia Risso et Poiteau, and its potential use in managing anxiety. This oil is currently being utilized in aromatherapy to reduce pain, help induce sleep, and/or minimize the impacts of stress-induced anxiety. Preclinical research has indicated that bermagot essential oils (BEOs) alter certain neurotransmissions and produce an effect similar to anxiolytic but not consistent with that of the benzodiazepine diazepam. Neurotransmissions other than GABAergic may therefore play a part in this mechanism. One of these is serotonergic (5-HT) neurotransmission, which is believed to have a function in anxiety. The 5-HT1A subtype of serotonergic receptors appear to play a particularly important role in anxiety. Rombolà et al. say that adjusting this 5-HT1A receptor may influence some of the anxiolytic-relaxant effects of bergamot essential oils.
[NPID: anxiety, herbs, motor, aromatherapy, Bergamot, serotonin, neurotransmission]

Year: 2020

Reference: Rombolà, L., Scuteri, D., Watanabe, C., Sakurada, S., Hamamura, K., Sakurada, T., Tonin, P., Corasaniti, M. T., Bagetta, G., & Morrone, L. A. (2020). Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent. International journal of molecular sciences, 21(7), 2597. https://doi.org/10.3390/ijms21072597