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The impact of nutritional support therapy combined with conventional treatment models on short-term symptom improvement and complications in stroke patients: a systematic review and meta-analysis
This study systematically assesses the effectiveness of nutritional support therapy alongside conventional treatment for short-term symptom improvement, nutritional and immune recovery, and complication rates in stroke patients. A comprehensive literature search was conducted across multiple databases, including PubMed, EMBASE, ScienceDirect, the Cochrane Library, and significant Chinese databases (CNKI, VIP, Wanfang, and CBM) from inception to the present. The review included randomized controlled trials (RCTs) that evaluated the effects of nutritional support in stroke patients. Data extraction was performed independently by two reviewers, and the Cochrane Handbook 5.3 was employed to evaluate the risk of bias. The meta-analysis utilized RevMan 5.3, adhering to PRISMA guidelines. Out of 1,693 records screened, 8 RCTs involving 727 participants were included. The meta-analysis demonstrated that nutritional support significantly improved Glasgow Coma Scale (GCS) scores, serum markers of nutritional status (hemoglobin, total lymphocyte count), and immune parameters (IgA, IgG, IgM). Additionally, levels of pro-inflammatory cytokines (IL-2, IL-6, TNF-α) were significantly reduced, and the incidence of infectious complications was lower in the intervention group. Despite these positive findings, the analysis revealed substantial heterogeneity across studies, warranting cautious interpretation of the results. While nutritional support combined with conventional therapy enhances nutritional and immune recovery and reduces the risk of infection in stroke patients, the high heterogeneity and methodological limitations of the included trials indicate that the certainty of evidence remains low to very low. [NPID: Nutritional therapy, stroke, pro-inflammatory cytokines, IgA, IgG, IgM)
Year: 2025
