N-3 (Omega-3) fatty acids: Effects on brain dopamine systems and potential role in the etiology and treatment of neuropsychiatric disorders

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Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: Relevance for major depression and for human hippocampal neurogenesis

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known for being able to ameliorate depressive symptoms and inflammation in addition to their neuroprotective effects. However, the mechanisms behind these properties remain poorly understood. In this study by Borsini et al. (2021), the authors conducted in vitro and clinical experiments to find out which EPA or […]

Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation

Supplementing with eicosapentaenoic acid (EPA) is known to be a successful therapy for major depressive disorder (MDD), a condition which is associated with persistent low-grade inflammation. EPA serves as a precursor to specialized pro-resolving lipid mediators (SPMs) known as resolvins (Rv), which play crucial roles in resolving inflammation. In this study by Lamon-Fava et al. […]