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Hunger, satiety, and their vulnerabilities
The psychological states of hunger and satiety are crucial in modulating human food intake, significantly influenced by declarative learning and memory processes primarily localized in the medial temporal lobes (MTL). The MTL, particularly the hippocampus, is notably susceptible to damage, prompting an examination of its impact on hunger and satiety across various conditions. This includes scenarios where MTL pathology is central to ingestive behavior, such as habitual Western-style diet consumption, obesity, and anorexia nervosa, and conditions with significant MTL involvement but less direct correlation to ingestive behavior, including temporal lobe epilepsy and post-traumatic stress disorder. Current evidence suggests a strong link between MTL impairment and dysfunctional hunger and satiety responses. These findings underscore the importance of focusing on the MTL and related cognitive processes, which could inform the development of innovative treatment strategies for appetite regulation. [NPID: hunger, satiety, appetite, declarative memory]
Year: 2024
