Mitochondrial dynamics in the brain are associated with feeding, glucose homeostasis, and whole-body metabolism

This 2020 study explains that while it is the brain’s responsibility to maintain whole-body homeostasis, it is the hypothalamus’ and dorsal vagal complex (DVC)’s role to regulate metabolic processes whilst sensing both hormones and nutrients. Haigh et al. (2020) highlight that the mitochondria contribute to the maintenance of energy homeostasis by responding to the level of nutrient availability, and metabolic diseases e.g. obesity and type 2 diabetes (T2D) disturb these processes. Mitochondria also plays a role in regulating glucose, and controlling whole-body metabolism, and therefore are pivotal in the development and maintenance of obesity and T2D. [NPID: brain, homeostasis, hypothalamus, hormones, mitochondria, obesity, type 2 diabetes, diabetes, glucose]

Year: 2020

Reference: Haigh, J. L., New, L. E., & Filippi, B. M. (2020). Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism. Frontiers in endocrinology, 11, 580879. https://doi.org/10.3389/fendo.2020.580879

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