Internal-state-dependent control of feeding behavior via hippocampal ghrelin signaling

Hansen et al. (2018) studied the effects of dyslipidemia (elevation of plasma cholesterol, triglycerides (TGs), or both, or low HDL cholesterol level) induced by two diets (high in fat with or without high sucrose) on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (BDNF), monoaminergic neurotransmitter concentration, and on down-stream markers of synaptic plasticity. […]

Consumption of a Western diet (WD) during early developmental stages is linked to memory problems, particularly affecting processes reliant on the hippocampus (HPC). To explore the neurobiological reasons behind this, Hayes et al. (2024) established a rodent model where early exposure to WD led to enduring dysfunction in the HPC. Rats were given either a […]