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Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression
Depression and anxiety are prevalent mental health disorders that affect around 20% of the global population. Research aimed at creating innovative treatment interventions is ongoing, however, current pharmacological treatment for emotional disorders require a long treatment course (up to weeks) before they start eliciting a positive response on a patient’s emotional state, not to mention the significant side effects associated with such interventions. Flavonoids are plant-derived natural compounds (in sources such as fruits, vegetables, and medicinal herbs) that have beneficial therapeutic properties, and have been shown to hold promise in the treatment of emotional disorders, such as anxiety and depression, through several studies. In this review, Ko et al. (2020) look at the recent evidence highlighting flavonoids as promising vectors for the treatment of depression and anxiety, and their use in the development of new interventional pharmacotherapeutics. The authors compiled current works which investigated distinct flavonoid compounds, outlined their mechanism of action in emotion-related disorders, and discussed their behavioral, molecular, physiological, and neurochemical aspects, be it on a cellular level or on animal models. [NPID: Anxiety, depression, emotional disorders, flavonoids, mechanisms of action, therapeutic effects]
Year: 2020
