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Associations of dietary patterns with psychological and inflammatory outcomes in colon cancer patients
Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay
Dietary patterns significantly influence psychological health, systemic inflammation, and gut microbiota composition in colon cancer patients. This study evaluates the associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) score and the Dietary Index for Gut Microbiota (DI-GM) with psychological outcomes, inflammatory markers, gut microbiota diversity (Shannon index), and composition (Firmicutes/Bacteroidetes ratio), as well as tumor biomarkers in a cohort of 630 colon cancer patients. A cross-sectional study design was employed, utilizing multivariate linear regression models adjusted for demographic, clinical, and dietary factors to assess the relationships between MIND and DI-GM scores and various outcomes, including depression, anxiety (HADS), sleep quality (PSQI), quality of life (FACT-C), inflammatory markers (CRP, IL-6, fecal calprotectin), F/B ratio, and tumor biomarkers (CEA, CA19-9). Higher MIND and DI-GM scores were significantly correlated with improved psychological outcomes and reduced systemic inflammation. A one-unit increase in the MIND score was associated with decreased levels of depression and anxiety. Furthermore, DI-GM scores exhibited an inverse relationship with depression, anxiety, and inflammatory markers. Notably, tumor biomarkers CA19-9 and CEA were significantly inversely associated with both dietary scores, particularly with DI-GM. The F/B ratio was found to partially mediate the relationship between dietary scores and psychological outcomes; however, it did not influence inflammatory markers. Adherence to MIND and DI-GM dietary patterns is linked to enhanced psychological health, reduced inflammation, and improved gut microbiota profiles in colon cancer patients. The DI-GM index may provide a more comprehensive understanding of the diet–gut microbiota–inflammation interplay, suggesting dietary interventions as a viable strategy to enhance patient well-being.
Year: 2025
