Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

This study conducted in 2022 examined a sample of middle-aged adults on the relationship between their gut microbiota and cognitive ability. The data was taken from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, which collected stool samples for DNA analysis in 2015 and 2016. Microbiome data were available on 597 CARDIA participants. […]

The gut microbiota significantly impacts brain function through the gut-brain axis, although the molecular mechanisms involved remain largely undefined. Central to this interaction are barrier systems, including the epithelial gut barrier and the blood-brain barrier, which facilitate the communication of circulating signals. Microbial metabolites play a crucial role in influencing the integrity of these barriers. […]