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Association of dietary saturated fatty acid intake with depression: mediating effects of the dietary inflammation index
Diet and dietary inflammation significantly impact depression. This study by Qi & Gou (2024) aimed to examine the link between saturated fatty acids (SFAs) and depression risk, as well as the role of the Dietary Inflammation Index (DII) as a mediator. Using data from 22,478 U.S. adults (aged 20 and older) from the National Health and Nutrition Examination Survey (NHANES), the study utilized univariate and multivariate logistic regression to explore the relationship between SFA intake and depression risk. DII was used to measure dietary inflammation. There was a notable difference in SFA intake between individuals with and without depression. After adjusting for confounding factors, the results indicated that certain SFAs might influence depression risk: medium-chain SFAs (8–12 carbons) could increase the risk, while long-chain SFA (≥ 14 carbons) might decrease it. The impact of different SFAs on depression varied by sex and age. 12-carbon SFAs intake leads to an increase in depression risk, however, in a non-linear manner. Finally, the authors found that DII mediated the link between SFAs and depression risk. The study suggests that SFA intake is linked to depression risk, with the effect varying by SFA chain length and potentially mediated by DII. [NPID: SFAs, DII, NHANES, depression, mediation]
Year: 2024
