Assessing the role of antioxidant and pro-oxidant balance in mediating the relationship between vitamin K intake and depressive symptoms in adults

Increasing evidence suggests a potential connection between vitamin K (VK) intake and depression, though the mechanisms are not fully understood. Wang et al. (2024) investigated the links between vitamin K (VK) consumption and depression, as well as the oxidative balance scores (OBS), using data from 30408 participants in the National Health and Nutrition Examination Survey (NHANES years 2007 to 2018). Analysis of the results revealed that higher VK intake was linked to a lower risk of depression. Compared to the lowest quartile of log2 VK intake, higher quartiles showed significantly reduced odds of depression. Furthermore, a 15% reduction in the likelihood of developing depression was linked to every unit increase in log2 VK consumption. It was also discovered that OBS mediated 26.09% of the correlation between log2 VK and depression. Increased VK intake appears to be associated with a lower risk of depression, potentially mediated by oxidative balance. To confirm these correlations and learn more about the underlying processes, the authors advise carrying out more research. [NPID: Depression, vitamin K, oxidative balance scores, NHANES, mediation analysis]

Year: 2024

Reference: Wang, L., Huang, S., Feng, Z., Xiao, J., Luo, G., & Zhang, Y. (2024). Assessing the role of antioxidant and pro-oxidant balance in mediating the relationship between vitamin K intake and depressive symptoms in adults. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1384489