Antidepressant effect of tetragonia tetragonoides (pall.) kuntzeextract on serotonin turnover

This 2019 study found that consuming tetragonia tetragonoides kuntze (TTK) extract can ameliorate the development of depressive-like symptoms in ovariectomized (OVX) rats. Tetragonia tetragonoides (pall.) kuntze (TTK) is a groundcover found along coastal areas of the Korean peninsula. It is used to improve women’s health and treat gastrointestinal diseases. To determine the mechanisms involved in the antidepressant-like effect of tetragonia tetragonoides kuntze (TTK) extract, this study analyzed the mRNA expression levels of tryptophan hydroxylases (TPH-1 and TPH-2) and serotonin transporter (SERT). In addition, the scientists monitored the reuptake activity of serotonin in RBL-2H3 cells. This study checked whether TTK extract can regulate the blood levels of serotonin and enhance depressive-like symptoms in OVX female rats fed 0.5, 1, and 2% TTK. The serum levels of serotonin of OVX female rats increased after the 1% and 2% TTK treatments. The forced swimming test showed reduced immobility times in the OVX female rats after the 1% and 2% TTK treatments. These results indicate that TTK may significantly inhibit depressive-like symptoms by increasing serotonin levels and regulating the serotonin reuptake activity. Individuals suffering from depression during pre- or/and postmenopausal periods (via modulation of serotonin synthesis and metabolism) may benefit from TTK. [NPID: tetragonia tetragonoides kuntze, TTK, depression, antidepressant, serotonin]

Year: 2019

Reference: Yang, H., Kim, H. J., Hong, E.-J., Pyun, B.-J., Ko, B.-S., & Lee, H. W. (2019). Antidepressant effect oftetragonia tetragonoides (pall.) kuntzeextract on serotonin turnover. Evidence-Based Complementary and Alternative Medicine, 2019, 1–7. https://doi.org/10.1155/2019/7312842

Related Studies

Therapeutic potential of hericium erinaceus for depressive disorder

This 2019 study explains why Hericium erinaceus, also known as Lion’s mane mushroom, may have a use case in depression. This mushroom has been shown to promote health, exerting antioxidative, antidiabetic, anticancer, anti-inflammatory, and antimicrobial effects. Hericium erinaceus has also been used in the treatment of cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Certain bioactive […]

Evaluation of antianxiety potential of four ganoderma (Agaricomycetes) species from India in mice

Among various medicinal mushroom species, the genus Ganoderma has many members that are known to reduce stress and anxiety. Research on their efficacy, however, is insufficient to date. This compelled Singh et al. (2016) to investigate the anxiolytic properties of four Ganoderma members, namely, G. applanatum, G. brownii, G. lucidum, and G. philippii. Dried, powdered […]