A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling (animal study)

While the two main components of the Western diet (saturated fats and simple carbohydrates) are linked with the development of obesity and Alzheimer’s disease, Kanoski & Davidson (2011) summarize the evidence indicating that the consumption of this Western diet is also associated with cognitive dysfunction. The focus is mainly on the learning and memory functions […]

Chronic stress encourages the consumption of palatable foods and can accelerate obesity. Although mechanisms that affect stress and feeding have been found, it is still unclear how stress-induced feeding is managed. Since the absence of Npy1r in these neurons reduces the obesifying effects of a combination of stress and a high-fat diet (HFDS) in mice, […]