Diet, Probiotics, and Psychobiotics

The CNP Diet, Probiotics, and Psychobiotics Research Category consolidates research exploring the interdependent relationship between probiotics, psychobiotics, and mental health. To view each original study on the open internet, click “Original.” To view the CNP-written abstract summary, click “CNP Summary.” While only some of the CNP-written abstract summaries are available below for free, all abstract summaries are available to CNP members through the CNP Library Membership.

2021

Probiotic consumption relieved human stress and anxiety symptoms via modulating the gut microbiota and neuroactive potential

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2022

Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial

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2022

Association between consumption of fermented food and food-derived prebiotics with cognitive performance, depressive, and anxiety symptoms in psychiatrically healthy medical students under psychological stress: A prospective cohort study

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2022

Effect of probiotics on psychiatric symptoms and central nervous system functions in human health and disease: A systematic review and meta-analysis

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CNP Research Summary can be found in the CNP Library Membership

2022

Lactobacillus rhamnosus CNCM I-3690 decreases subjective academic stress in healthy adults: a randomized placebo-controlled trial

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2018

Effects of prebiotic galacto-oligosaccharide on postoperative cognitive dysfunction and neuroinflammation through targeting of the gut-brain axis

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CNP Research Summary can be found in the CNP Library Membership

2017

Targeting the Microbiota-Gut-Brain Axis: Prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice

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2021

Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition

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CNP Research Summary can be found in the CNP Library Membership

2021

Nutrient intake and gut microbial genera changes after a 4-week placebo controlled galacto-oligosaccharides intervention in young females

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2021

Effect of psychobiotics on psychometric tests and inflammatory markers in Major Depressive Disorder: Meta-analysis of randomized controlled trials with meta-regression

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CNP Research Summary can be found in the CNP Library Membership

2021

Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial

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2020

Oral administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 improves the mild-to-moderate symptoms of depression: A randomized, double-blind, placebo-controlled study

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CNP Research Summary can be found in the CNP Library Membership

2019

Probiotics: a potential immunotherapeutic approach for the treatment of schizophrenia

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2018

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

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CNP Research Summary can be found in the CNP Library Membership

2019

Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study

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2017

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

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CNP Research Summary can be found in the CNP Library Membership

2018

The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature

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2020

Probiotics in psychosocial stress and anxiety. A systematic review

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CNP Research Summary can be found in the CNP Library Membership

2017

Probiotics and subclinical psychological symptoms in healthy participants: A systematic review and meta-analysis

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2018

A meta-analysis of the use of probiotics to alleviate depressive symptoms

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CNP Research Summary can be found in the CNP Library Membership

2015

A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood

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2019

Microbiota and memory: A symbiotic therapy to counter cognitive decline?

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CNP Research Summary can be found in the CNP Library Membership

2019

Probiotic supplementation attenuates hippocampus injury and spatial learning and memory impairments in a cerebral hypoperfusion mouse model

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2018

The effects of probiotics on mood and emotion

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CNP Research Summary can be found in the CNP Library Membership

2019

The gut-brain relationship: Investigating the effect of multispecies probiotics on anxiety in a randomized placebo-controlled trial of healthy young adults

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2016

Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials

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CNP Research Summary can be found in the CNP Library Membership

2020

Supplementation with combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 across development reveals sex differences in physiological and behavioural effects of western diet in Long–Evans rats (animal)

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2017

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

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CNP Research Summary can be found in the CNP Library Membership

2018

Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?

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2019

Gut feeling: randomized controlled trials of probiotics for the treatment of clinical depression: Systematic review and meta-analysis

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CNP Research Summary can be found in the CNP Library Membership

2018

Effect of a multistrain probiotic (Lactoflorene ® Plus) on inflammatory parameters and microbiota composition in subjects with stress-related symptoms

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2020

Effects of a psychobiotic supplement on serum brain-derived neurotrophic factor levels in depressive patients: A post hoc analysis of a randomized clinical trial

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CNP Research Summary can be found in the CNP Library Membership

2019

Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews

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2019

Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study

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CNP Research Summary can be found in the CNP Library Membership

2019

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

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2016

Effect of probiotics on depression: A systematic review and meta-analysis of randomized controlled trials

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CNP Research Summary can be found in the CNP Library Membership

2016

Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial

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2020

The effects of probiotics and prebiotics on mental disorders: A review on depression, anxiety, Alzheimer, and Autism Spectrum Disorders

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CNP Research Summary can be found in the CNP Library Membership

2019

The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorder patients using gluten-free or gluten-containing diet (SANGUT study): a 12-week, randomized, double-blind, and placebo-controlled clinical study protocol

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2019

Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial

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