The role of IL-1 in postprandial fatigue

Lehrskov et. al (2018) here investigated whether postprandial (post-meal) fatigue is regulated by the cytokine IL-1 (which seems to play a role in the pathogenesis of fatigue associated with some chronic diseases) by testing the effect of an IL-1 receptor antagonist in lean and obese subjects. In this double-blind crossover study, 16 male individuals (8 lean, 8 obese) were randomly assigned to receive either the placebo (saline) or the IL-1 receptor antagonist anakinra, and were given a high-fat, high-carbohydrate meal 30 minutes after the subjects ran. Fatigue was determined using the Stanford Sleepiness Scale and blood samples were drawn at baseline and after the intervention. The results showed a reduction in postprandial fatigue in the individuals who were given the IL-1 antagonist, with the effect more pronounced in the obese group than those lean participants. These researchers have concluded IL-1 is involved in the regulation of postprandial fatigue under physiological conditions in lean and obese individuals. [NPID: pain, fatigue, postprandial fatigue, post-meal fatigue, chronic disease, sleep, obesity]

Year: 2018

Reference: Lehrskov, L. L., Dorph, E., Widmer, A. M., Hepprich, M., Siegenthaler, J., Timper, K., & Donath, M. Y. (2018). The role of IL-1 in postprandial fatigue. Molecular metabolism, 12, 107–112. https://doi.org/10.1016/j.molmet.2018.04.001

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