The relationship between dietary vitamin K and depressive symptoms in late adulthood: A cross-sectional analysis from a large cohort study

This 2019 study assessed the correlation between dietary vitamin K intake (data collected through a semi-quantitative food frequency questionnaire) and depressive symptoms [diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16] among 4,375 adult participants (aged 45-79) from North America. Around 10% (n=437) of the subjects exhibited symptoms of depression. After adjusting for potential confounders in the logistic regression analysis, those adults with the highest vitamin k intake were associated with lower incidences of depressive symptoms (OR = 0.58; 95%CI: 0.43–0.80), although this observation only applied to subjects not taking vitamin D supplements. Since this study provides evidence on the relevance of higher dietary vitamin K with lower appearance of depressive symptoms, further research is encouraged, especially to inspect the directionality of this association. [NPID: micronutrients, nutritional supplements, vitamin K, depression, vitamin D]

Year: 2019

Reference: Bolzetta, F., Veronese, N., Stubbs, B., Noale, M., Vaona, A., Demurtas, J., Celotto, S., Cacco, C., Cester, A., Caruso, M. G., Reddavide, R., Notarnicola, M., Maggi, S., Koyanagi, A., Fornaro, M., Firth, J., Smith, L., & Solmi, M. (2019). The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients, 11(4), 787. https://doi.org/10.3390/nu11040787