The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts

The skin, as the body’s largest organ, consists of three layers: the epidermis, dermis, and hypodermis. The dermis contains dermal fibroblasts and an extracellular matrix, including collagen and elastin, which are crucial for skin’s elasticity and firmness. Skin aging is accelerated by environmental factors such as UV radiation, pollution, and smoking through the generation of reactive oxygen species and related signaling pathways. These factors contribute to reduced elasticity, wrinkle formation, and slower wound healing. Research has indicated that natural polyphenol compounds can slow these aging effects by modulating signaling pathways in aged dermal fibroblasts. This paper examines the links between aging and its molecular mechanisms and explores how various polyphenols can enhance skin health, providing valuable insights for the development of functional cosmetics and potential clinical applications.

Year: 2022

Reference: Lee, J. H., Park, J., & Shin, D. W. (2022). The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts. Molecules (Basel, Switzerland), 27(14), 4351. https://doi.org/10.3390/molecules27144351