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The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets
In the past few years, the study of the human gut microbiome has enabled us to comprehend its significance for overall human health, leading to the identification of various functional axes, including the gut-brain, gut-liver, and gut-lung axes. These axes, in turn, attribute an organ-like status to this microecological component of our body. While the human gut microbiota is highly diverse, it can be modified utilizing diet, making it possible to target microbes through well-defined dietary strategies. This presents an opportunity to develop cost-effective therapies that can alleviate the burden of non-communicable diseases, such as the global obesity and overweight pandemic, and its metabolic comorbidities. However, randomly managed dietary treatments frequently have low to middling success rates in weight management, which makes their application in clinical practice challenging. In this review by Hernández-Calderón, Wiedemann & Benítez-Páez (2022), the authors investigate the prognostic significance of initial human gut microbiome compositions to forecast the efficacy of dietary weight reduction treatments, primarily based on calorie limitation plans and oral fiber supplementation. By taking into account various dietary trends and selecting the ideal one based on each individual’s microbiota makeup, the authors argue that their study integrates into precision medicine to significantly reduce adiposity and enhance metabolic state. The findings from this novel line of inquiry are examined, taking into consideration recently published works. Intending to acquire knowledge in the area and make advancements in tailored nutrition, the authors discuss future outlooks and possible mistakes to avoid. [NPID: weight loss, dietary interventions, obesity, metabolic disease, gut microbiota, personalized nutrition]
Year: 2022
