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The impact of depression-mediated gut microbiota composition on Irritable Bowel Syndrome: A Mendelian study
In order to examine the causative association between gut microbiota and the onset of irritable bowel syndrome (IBS), as well as the possible moderating role of depression in this relationship, this study by Huang et al. (2024) used a two-sample Mendelian randomization (MR) technique. Multiple two-sample MR methods were utilized to examine the causal effects of gut microbiota on IBS and depression. The two-sample MR analysis revealed a significant causal relationship between specific bacterial groups in the gut microbiota and the development of IBS. Notable bacteria included p_Actinobacteria, c_Clostridia, s_Desulfovibrio_piger, g_Streptococcus, and c_Actinobacteria. Further analysis demonstrated that depression significantly influenced IBS in various models. Mediation analysis showed that c_Clostridia and o_Clostridiales bacteria affected IBS indirectly through depression. The findings point to a clear causal link between the development of IBS and the makeup of the gut microbiota. Moreover, depression acts as a mediator for specific gut bacteria, contributing to the onset of IBS. These findings suggest that mental health interventions targeting depression may help reduce the risk of IBS triggered by adverse gut microbiota profiles. [NPID: Mendelian randomization, gut microbiota, irritable bowel syndrome, depression, mediation analysis, IBS onset, mental health interventions]
Year: 2024
