The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?

This 2020 review evaluated the current evidence on the impact of gut microbes on cerebral blood-brain barrier (BBB) integrity. Upon describing the destruction of the BBB through the influences of microbiota and its metabolites on the nervous, endocrine, and immune systems and signaling pathways, Tang et al. (2020) suggests ways in which the BBB can […]

Trillions of viruses, bacteria, and fungi live in the digestive system and make up the gut microbiome. These communities are vulnerable to environmental stressors like disease or dietary modifications. Disruption of the Lactobaccillacea population, which produces lactic acid, has been linked to stress exposure and mood problems. In reality, these effects can be mitigated, and […]